Imprint of unconventional Tcell response in acute hepatitis C persists despite successful early antiviral treatment

Y Du, T Khera, B Strunz, K Deterding… - European Journal of …, 2022 - Wiley Online Library
T cells also exhibit an activated phenotype but are less efficient in producing cytokines during
chronic … At the same time, intrahepatic levels of γδ T cells were increased [37]. In line with …

[HTML][HTML] Longitudinal characterization of phenotypic profile of T cells in chronic hepatitis B identifies immune markers associated with HBsAg loss

S Xiong, D Zhu, B Liang, M Li, W Pan, J He, H Wang… - …, 2021 - thelancet.com
… analysis of the T cell phenotype and function during the … , T cell phenotype profiles and
HBV-specific T cell responses … to, during and after achieving functional cure upon treatment and …

[HTML][HTML] Genetic and phenotypic difference in CD8+ T cell exhaustion between chronic hepatitis B infection and hepatocellular carcinoma

X Wang, Q He, H Shen, XJ Lu, B Sun - Journal of medical genetics, 2019 - jmg.bmj.com
phenotypes and functional states of CD8 + T cells separating from human CHB tissues and
HCC tissues, and re-analyse the single-cell … B (CHB)/chronic hepatitis C and hepatocellular …

[HTML][HTML] Exhausted phenotype of circulating CD8+ T cell subsets in hepatitis B virus carriers

D Jiang, C Chen, D Yan, X Zhang, X Liu, D Yan, D Cui… - BMC immunology, 2022 - Springer
Chronic hepatitis B virus (HBV) infection is characterized by the … CD8 + T cells that hamper
viral control. We investigated the phenotypic heterogeneity of exhausted CD8 + T cells in HBV

[HTML][HTML] Distinct phenotype and function of circulating Vδ1+ and Vδ2+ γδT-cells in acute and chronic hepatitis B

…, Hepatitis B Research Network (HBRN) - PLoS …, 2019 - journals.plos.org
… They were also negative for serum HBsAg, antibody to hepatitis C virus (anti-HCV) and … the
intrahepatic compartment which is enriched in γδT-cells, although both Vδ1 + and Vδ2 + γδT-…

… in Natural Killer and T cell Phenotypes with Evaluation of Immune Outcome in a Longitudinal Cohort Following Sofosbuvir-Based Therapy for Chronic Hepatitis C …

…, C Homan, P Holck, SV Luna, C Knall… - Open forum …, 2019 - academic.oup.com
… NK and T cell composition and phenotypes. Chronic HCV infection promotes adverse NK cell
… We cannot make inferences regarding intrahepatic cell populations in this study. The small …

Chronic genotype 1 hepatitis C along with cirrhosis drives a persistent imprint in virus‐specific CD8+ T cells after direct‐acting antiviral therapies

…, Z Mariño, S Lens, T Leonel, C Bartres… - … of Viral Hepatitis, 2020 - Wiley Online Library
… To analyse the phenotype of virus-specific CD8 + T cells, we investigated the expression …
that chronic hepatitis C creates a profound exhausted signature in HCV-specific CD8 + T cells

[HTML][HTML] Double Positive CD4+CD8+ (DP) T-Cells Display Distinct Exhaustion Phenotype in Chronic Hepatitis C

AM Kochanowicz, S Osuch, H Berak, A Kumorek… - Cells, 2023 - mdpi.com
T-cells, which may display a distinct exhaustion phenotype from intrahepatic T-cells. Since
… characterization of DP T-cellsphenotype rather than their functional features. Nevertheless, …

[HTML][HTML] Phenotype and fate of liver-resident CD8 T cells during acute and chronic hepacivirus infection

P Dravid, S Murthy, Z Attia, C Cassady… - PLoS …, 2023 - journals.plos.org
… Approximately 60–80% of humans fail to clear the hepatitis C virus infection, and the … ability
of RHV-specific T cells, we stimulated the intrahepatic leukocytes ex vivo using class I and …

Chemokine-regulated recruitment of antigen-specific T-cell subpopulations to the liver in acute and chronic hepatitis C infection

MR Pirozyan, N Nguyen, B Cameron… - The Journal of …, 2019 - academic.oup.com
… In HCV, intrahepatic T cells express chemokine receptors (… + CD8 + T cells predominantly
had a resting phenotype and … showed more activation and effector status, and rapidly reduced …